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Oxycodone is a potent semisynthetic opioid with agonistic properties on mu-, kappa-, and delta-type opioid receptors. This drug is beneficial when used judiciously for pain management, yet it carries the risk of inducing physical dependence and addiction. The immediate-release formulation of oxycodone is approved by the US Food and Drug Administration (FDA) for managing acute or chronic moderate-to-severe pain when opioid medication is considered suitable and alternative pain management strategies are inadequate. The extended-release formulation is FDA-approved for managing severe pain that necessitates continuous, long-term opioid treatment when no alternative options are available to address the pain.The FDA has also approved an abuse-deterrent formulation of oxycodone, containing inactive ingredients to render the formulation resistant to misuse and abuse. This activity comprehensively reviews the indications, mechanism of action, administration, adverse effects, and contraindications of oxycodone while highlighting its distinctions from other opioids in pain management. This activity also underscores the crucial role of the interprofessional healthcare team in assisting patients with pain management with oxycodone.
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