Buy Hydrocodone Online is metabolized in the liver, primarily by the enzyme CYP3A4, and excreted through the kidneys. Because of this, patients with liver or kidney issues need careful monitoring and possible dose adjustments to avoid toxicity. Additionally, combining hydrocodone with other medications that inhibit the CYP3A4 enzyme, such as certain antibiotics, antifungals, or HIV medications, can lead to dangerously high levels of hydrocodone in the bloodstream, increasing the risk of overdose.