Percocet is a prescription medication typically used to treat mild, moderate, or severe pain for those whose other treatments may not be enough. This combination medication contains two active ingredients: oxycodone, a potent opioid analgesic, and acetaminophen, one of the most common non-opioid analgesics. Together, they prevent the pain from signaling to the brain, hence useful in post-surgical pain, injury-related pain, and sometimes severe chronic pain.