Under the brand name Ultram, tramadol received approval to be sold as a non-controlled analgesic in the US in 1995. However, there have been instances of tramadol abuse and diversion shortly after it was approved. As a result, the Food and Drug Administration (FDA) included warnings concerning its abuse and changed the product's label. Being an opioid analgesic, the primary factor influencing the pharmacological effects of tramadol is opioid activity. Buy Tramadol 100mg Online other opioid analgesics, tramadol can be abused and cause negative side effects. Moderate to severe pain syndrome (especially in the postoperative period, trauma, and malignant tumors). Alleviation of discomfort during arduous medical or diagnostic procedures.