Azithromycin is a commonly prescribed antibiotic used to treat various bacterial infections, including respiratory infections, ear infections, and sexually transmitted diseases. While generally well-tolerated, the most common side effect of Azee 500 is gastrointestinal upset, with diarrhea being the number one complaint among patients.

This occurs because antibiotics like azithromycin not only target harmful bacteria but can also disrupt the balance of good bacteria in the gut, leading to digestive issues. Diarrhea may be mild and resolve on its own, but in rare cases, it can become severe or signal a more serious condition such as Clostridioides difficile (C. diff) infection, which requires immediate medical attention.

To minimize this risk, patients are often advised to take azithromycin with food and stay hydrated. If diarrhea persists or is accompanied by abdominal pain or fever, it’s essential to consult a healthcare provider promptly.