Hydrocodone 10-500 mg is a prescription medication that combines two active ingredients: hydrocodone bitartrate (10 mg) and acetaminophen (660 mg). It was formerly prescribed to treat moderate to moderately severe pain, particularly in cases where non-opioid pain relievers were insufficient. This combination was once common in the U.S., but it is now discontinued or rarely used due to safety concerns, particularly related to the high dose of acetaminophen.