https://medixway.com/adhd/adderall/ Your first Adderall tablet dose of the day should be taken when you first wake up. This is usually in the morning. If your doctor recommends it, you may take one or two additional doses throughout the day separated by 4 to 6 hours. However, avoid taking Adderall late in the afternoon or evening. This is because Adderall may disrupt your sleep.Adderall XR capsule should be taken once daily after you first wake up. Most people take it in the morning. Taking this form of the medication in the afternoon isn’t usually recommended because the drug may disrupt your sleep.