If acclimatization is key, and how to reach Ladakh then the Srinagar‑Leh route is usually a gentler option for gradually gaining altitude compared to the Manali‑Leh route, which hits higher passes much sooner. The way you travel—by road or by air—also plays a significant role: Flying in means you experience a sudden change in altitude, so it's wise to take a day or two to rest in Leh. On the other hand, traveling by road allows for a more gradual ascent, which helps your body adjust better.